Home
HelpTest ID: DLAU D-Lactate, Urine
Reporting Name
D-Lactate, UUseful For
Preferred test for diagnosing D-lactate acidosis, especially in patients with jejunoileal bypass and short-bowel syndrome
Specimen Type
UrineSpecimen Required
Container/Tube: Plastic, 10-mL urine tube (T068)
Specimen Volume: 2.5 mL
Collection Instructions:
1. Collect a timed or random urine specimen.
2. No preservative.
3. Immediately freeze specimen.
Specimen Minimum Volume
0.65 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Frozen (preferred) | 365 days | |
| Refrigerated | 7 days | ||
| Ambient | 72 hours |
Reference Values
0.0-0.25 mmol/L
Day(s) Performed
Wednesday, Friday
Test Classification
This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83605
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| DLAU | D-Lactate, U | 14046-7 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8873 | D-Lactate, U | 14046-7 |
Clinical Information
D-lactate is produced by bacteria residing in the colon when carbohydrates are not completely absorbed in the small intestine. When large amounts of D-lactate are present, individuals can experiencemetabolic acidosis, altered mental status (from drowsiness to coma) and a variety of other neurologic symptoms, in particular dysarthria and ataxia. Although a temporal relationship has been described between elevations of plasma and urine D-lactate and the accompanying encephalopathy, the mechanism of neurologic manifestations has not been elucidated.
D-lactic acidosis is typically observed in patients with a malabsorptive disorder, such as short-bowel syndrome, or following jejunoileal bypass. In addition, healthy children presenting with gastroenteritis may also develop the clinical presentation of D-lactic acidosis.
Routine lactic acid determinations in blood will not reveal abnormalities because most lactic acid assays measure only L-lactate. Accordingly, D-lactate analysis must be specifically requested (eg, DLAC / D-Lactate, Plasma). However, as D-lactate is readily excreted in urine, this is the preferred specimen for D-lactate determinations.
Interpretation
Increased levels are diagnostic.
Clinical Reference
1. Brandt RB, Siegel SA, Waters MG, Bloch MH: Spectrophotometric assay for D-(-)-lactate in plasma. Anal Biochem. 1980;102(1):39-46
2. Petersen C: D-lactic acidosis. Nutr Clin Pract. 2005 Dec;20(6):634-645
3. Kowlgi NG, Chhabra L: D-Lactic acidosis: An underrecognized complication of short bowel syndrome. Gastroenterol Res Pract. 2015;2015:476215. doi: /10.1155/2015/476215
Report Available
4 to 8 daysMethod Name
Enzymatic
Forms
Special Instructions
mml-biochemical