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Test ID: CHRBF Chromosome Analysis, Body Fluid

Useful For

Assisting in the diagnosis of certain malignancies

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
_ML20 Metaphases, 1-19 No, (Bill Only) No
_M25 Metaphases, 20-25 No, (Bill Only) No
_MG25 Metaphases, >25 No, (Bill Only) No
_STAC Ag-Nor/CBL Stain No, (Bill Only) No

Testing Algorithm

This test includes a charge for cell culture of fresh specimens and professional interpretation of results. Analysis charges will be incurred for total work performed, and generally include 2 banded karyograms and the analysis of 20 metaphase cells. If no metaphase cells are available for analysis, no analysis charges will be incurred. If additional analysis work is required, additional charges may be incurred.


Method Name

Cell Culture followed by Chromosome Analysis

Reporting Name

Chromosomes, Body Fluid

Specimen Type

Body Fluid

Specimen Required

Provide a reason for referral and the specimen source with each specimen. The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be compromised or delayed.


Container/Tube: Sterile container

Specimen Volume: 25-50 mL

Collection Instructions: Collect specimen in a sterile syringe.

Additional Information: Advise Express Mail or equivalent, if not on courier service.

Specimen Minimum Volume

20 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Body Fluid Refrigerated (preferred)

Clinical Information

Cytogenetic studies on body fluids (eg, pleural effusions, ascites, and pericardial, cerebrospinal, and synovial fluids) may be helpful to diagnose or to rule-out metastases or relapses in patients with lymphoma or other malignancies.


Chromosome analysis serves as a useful adjunct to cytology. In pleural fluids, lymphomas are often more readily diagnosed by cytogenetic techniques than by standard cytologic examination.

Reference Values

An interpretive report will be provided.


The observation of a chromosomally abnormal clone is evidence of a clonal neoplastic process.


A normal karyotype does not eliminate the possibility of a neoplastic process.


On rare occasions, the presence of an abnormality may be associated with a congenital abnormality that is not related to a malignant neoplastic process. Follow-up with a medical genetics consultation is recommended.

Clinical Reference

Dewald GW, Dines DE, Weiland LH, Gordon H: The usefulness of chromosome examination in the diagnosis of malignant pleural effusions. N Engl J Med 1976;295:1494-1500

Day(s) and Time(s) Performed

Specimens are processed Monday through Sunday.

Results reported Monday through Friday, 8 a.m.-5 p.m.

Analytic Time

13 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

88239, 88291- Tissue culture for tumor, Interpretation and report

88264 w/modifier 52-Chromosome analysis less than 20 cells (if appropriate)

88264-Chromosome analysis with 20 to 25 cells (if appropriate)

88264, 88285-Chromosome analysis with greater than 25 cells (if appropriate)

88283-Additional specialized banding technique (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CHRBF Chromosomes, Body Fluid In Process


Result ID Test Result Name Result LOINC Value
52342 Result Summary 50397-9
52344 Interpretation 69965-2
52343 Result 82939-0
CG772 Reason for Referral 42349-1
52345 Specimen 31208-2
52346 Source 31208-2
52348 Method 49549-9
52347 Banding Method 62359-5
54627 Additional Information 48767-8
52349 Released By 18771-6
Mayo Clinic Laboratories | Genetics and Pharmacogenomics Catalog Additional Information: