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Test ID: DLAC D-Lactate, Plasma

Reporting Name

D-Lactate, P

Useful For

An adjunct to urine D-lactate (preferred), in the diagnosis of D-lactate acidosis

Specimen Type

Plasma NaFl-KOx


Specimen Required


Collection Container/Tube: Grey top (potassium oxalate/sodium fluoride) (Supply T275)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Spin down and immediately freeze specimen.

Additional Information: For L-lactate (lactic acid), order LLA / Lactate, Plasma.


Specimen Minimum Volume

0.55 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma NaFl-KOx Frozen (preferred) 365 days
  Ambient  7 days
  Refrigerated  7 days

Reference Values

0.0-0.25 mmol/L

Day(s) and Time(s) Performed

Monday, Thursday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

83605

LOINC Code Information

Test ID Test Order Name Order LOINC Value
DLAC D-Lactate, P 14045-9

 

Result ID Test Result Name Result LOINC Value
8878 D-Lactate, P 14045-9

Clinical Information

D-lactate is produced by bacteria residing in the colon when carbohydrates are not completely absorbed in the small intestine. When large amounts of D-lactate are present, individuals can experience metabolic acidosis, altered mental status (from drowsiness to coma), and a variety of other neurologic symptoms, particularly dysarthria and ataxia.

 

D-lactic acidosis is typically observed in patients with a malabsorptive disorder, such as short-bowel syndrome, or, following a jejunoileal bypass. In addition, healthy children presenting with gastroenteritis may also develop the critical presentation of D-lactic acidosis.

 

Routine lactic acid determinations in blood will not reveal abnormalities because most lactic acid assays measure only L-lactate. Accordingly, D-lactate analysis must be specifically requested (eg, DLAC / D-Lactate, Plasma). However, as D-lactate is readily excreted in urine, DLAU / D-Lactate, Urine is the preferred specimen for D-lactate determinations.

Interpretation

Increased levels are consistent with D-lactic acidosis. However, because D-lactate is readily excreted, urine determinations are preferred.

Clinical Reference

1. Brandt RB, Siegel SA, Waters MG, Bloch MH: Spectrophotometric assay for D-(-)-lactate in plasma. Anal Biochem1980;102(1):39-46

2. Petersen C: D-lactic acidosis. Nutr Clin Pract 2005;20(6):634-645

Analytic Time

4 days

Method Name

Enzymatic

Testing Algorithm

DLAU / D-Lactate, Urine is the preferred specimen for D-lactate determinations.

Mayo Medical Laboratories | Genetics and Pharmacogenomics Catalog Additional Information:

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